Synthesis of a series of 2-(aminomethyl)-9-(2-phosphonomethoxyalkyl)adenines VI and hypoxanthines VII is reported. The protected 2-(aminomethyl)adenine I was selectively alkylated with [bis(2-propoxy)phosphonylmethoxy]alkyl chlorides or tosylates II and the obtained 9-[bis(2-propoxy)phosphonylmethoxy]alkyl-2-(benzyloxycarbonyla minomethyl)adenines IV were oxodeaminated to give the corresponding hypoxanthine derivatives V . The intermediates IV and V were completely deprotected by treatment with iodotrimethylsilane under formation of the title compounds VI and VII .