Dissemin is shutting down on January 1st, 2025

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Elsevier, Hematology/Oncology Clinics of North America, 2(23), p. 361-376, 2009

DOI: 10.1016/j.hoc.2009.01.006

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Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure; Future Prospects for Leukemia Prevention

Journal article published in 2009 by Grover C. Bagby ORCID, Gabrielle Meyers
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.