Published in
Institute of Organic Chemistry & Biochemistry, Collection of Czechoslovak Chemical Communications, 2(64), p. 229-241, 1999
DOI: 10.1135/cccc19990229
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Perfluoroalkylation of 6-iodopurines by trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(perfluoroalkyl)purine bases, nucleosides and acyclic nucleotide analogues
Journal article published in 1999 by
Michal Hocek 
,
Antonín Holý
,
Antonín Holý
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Abstract
A CuI/KF mediated perfluoroalkylation reaction of various 9-substituted 6-iodopurines 1 with trimethyl(trifluoromethyl)silane or heptafluoropropyl(trimethyl)silane was used for the synthesis of the corresponding 6-(trifluoromethyl)- and 6-(heptafluoropropyl)purine derivatives (purine bases, nucleosides and acyclic nucleotide analogues) in moderate to good yields.