The development of new laser systems based on OPCPA will push Laser Wakefield Accelerators (LWFA) to a qualitatively new energy range. As in the past, numerical simulations will play a critical role in testing, probing and optimizing the physical parameters and setup of these upscale experiments. Based on the prospective design parameters for the future Vulcan 10 PW OPCPA laser system, we have determined the optimal parameters for a single LWFA stage from theoretical scalings for such system, which predict accelerations to the energy frontier, with self-injected electrons in excess of 10 GeV for a self-guided configuration, and above 50 GeV bunches with externally-injected electrons in a laser-guided configuration. These parameters were then used as a baseline for 3D full scale simulations with OSIRIS and QuickPIC. A 12 GeV self-injected beam was obtained with both codes, in agreement with theoretical predictions for the maximum energy gain and the injected charge. Preliminary results on the laser-guided configuration already confirm the accelerating gradients and the stability of the laser guided propagation for long distances required to reach the higher energies predicted by the theoretical scalings for this scenario. © 2009 American Institute of Physics.