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BioMed Central, BMC Bioinformatics, 1(15), 2014

DOI: 10.1186/1471-2105-15-169

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A semi-automated technique for labeling and counting of apoptosing retinal cells

Journal article published in 2014 by Mukhtar Bizrah, Steve C. Dakin, Li Guo, Farzana Rahman, Miles Parnell, Eduardo Normando ORCID, Shereen Nizari, Benjamin Davis, Ahmed Younis, M. Francesca Cordeiro, M. Francesca Cordeiro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Retinal ganglion cell (RGC) loss is one of the earliest and most important cellular changes in glaucoma. The DARC (Detection of Apoptosing Retinal Cells) technology enables in vivo real-time non-invasive imaging of single apoptosing retinal cells in animal models of glaucoma and Alzheimer's disease. To date, apoptosing RGCs imaged using DARC have been counted manually. This is time-consuming, labour-intensive, vulnerable to bias, and has considerable inter- and intra-operator variability