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Oxford University Press, The Oncologist, 6(18), p. 651-652, 2013

DOI: 10.1634/theoncologist.2013-0190

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Cancer Clinical Trials—Do We Need a New Algorithm in the Age of Stratified Medicine?

Journal article published in 2013 by James H. Doroshow, Stefan Sleijfer, Roger Stupp, Kenneth Anderson
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The explosion in genomic discovery science and its application in oncology in recent years is underpinning an unprecedented increase in our understanding of mechanisms underlying malignant processes. An increased understanding creates challenges pertinent to the area of cancer clinical trial development and application. Although the existing cancer clinical trial algorithm has served us well in the past, is it still fit for purpose in the 21st century?