The frequency of intercultural contact in the South African workplace has increased after 1994. We investigated relations between adverse acculturation conditions, separation and well-being in Black and White miners. We utilized a cross- sectional design with a convenience sample of 241 Black and White miners. We then considered the effect of race in the experiences of miners and also used multigroup path analysis to determine whether identical relations between multiculturalism, work success, and wellbeing were could be found for Blacks and Whites. Mainstream segregation demands, discrimination, subtle racism and separation were strongly related to Ill-health symptoms, but not to work success. In addition, these relationships were Identical for Blacks and Whites. Separation fully mediated the relation between segregation and subtle racism and Ill-health. Adverse conditions matters for ill-health and well-being and therefore warrant the attention of supervisors in the workplace. Future studies should consider the role of multiculturalism In well-being.