We describe our efforts to understand large-scale (10's-100's kpc) relativistic jet systems through observations of the highest-redshift quasars. Results from a VLA survey search for radio jets in ~30 z>3.4 quasars are described along with new Chandra observations of 4 selected targets. ; Comment: 5 pages, 2 figures, to appear in Extragalactic Jets: Theory and Observation from Radio to Gamma Ray, Eds. T.A. Rector and D.S. De Young