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Cold Spring Harbor Laboratory Press, Genome Research, 5(14), p. 988-995, 2004

DOI: 10.1101/gr.1865504

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GeneWise and Genomewise

Journal article published in 2004 by Ewan Birney ORCID, Michele Clamp, Richard Durbin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.