Published in

Oxford University Press, Nucleic Acids Research, 1(25), p. 226-230, 1997

DOI: 10.1093/nar/25.1.226

Oxford University Press, Nucleic Acids Research, 1(24), p. 201-205, 1996

DOI: 10.1093/nar/24.1.201

Oxford University Press, Nucleic Acids Research, 13(21), p. 3105-3109, 1993

DOI: 10.1093/nar/21.13.3105

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The HSSP data base of protein structure-sequence alignments.

Journal article published in 1993 by Chris Sander, Reinhard Schneider ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

HSSP is a derived database merging structural three dimensional (3-D) and sequence one dimensional(1-D) information. For each protein of known 3-D structure from the Protein Data Bank (PDB), the database has a multiple sequence alignment of all available homologues and a sequence profile characteristic of the family. The list of homologues is the result of a database search in Swissprot using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed homologues are very likely to have the same 3-D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of aligned sequence families, but also a database of implied secondary and tertiary structures covering 27% of all Swissprot-stored sequences.