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American Society for Microbiology, Infection and Immunity, 3(81), p. 723-732, 2013

DOI: 10.1128/iai.00969-12

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Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice

Journal article published in 2012 by Simon Clare, Victoria John, Alan W. Walker ORCID, Jennifer L. Hill, Cei Abreu-Goodger, Christine Hale, David Goulding, Trevor D. Lawley, Pietro Mastroeni, Gadi Frankel, Anton J. Enright ORCID, Elena Vigorito, Gordon Dougan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT MicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosal Citrobacter rodentium infection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higher C. rodentium burden in gastrointestinal tissue and spread into systemic tissues. Germinal center formation and humoral immune responses against C. rodentium were severely impaired in infected miR-155-deficient mice. A similarly susceptible phenotype was observed in μMT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen.