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Thieme Gruppe, Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 10(2008), p. 1510-1514, 2008

DOI: 10.1055/s-2007-1077795

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Synthesis of 8-Heteroaryl-2′-deoxyguanosine Derivatives

This paper is available in a repository.
This paper is available in a repository.

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Abstract

We describe the synthesis of 8-heteroaromatic-2′-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2′-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.