Published in
Wiley Open Access, Molecular Systems Biology, 1(8), p. 572, 2012
DOI: 10.1038/msb.2012.3
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- [www.ncbi.nlm.nih.gov] | PDF
- [jdc.jefferson.edu] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels
Journal article published in 2012 by
Milana Frenkel-Morgenstern,
Tamar Danon,
Thomas Christian,
Takao Igarashi,
Lydia Cohen,
Ya-Ming Hou,
Lars Juhl Jensen 
This paper is made freely available by the publisher.
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Abstract
Most cell cycle-regulated genes adopt non-optimal codon usage, namely, their translation involves wobbly matching codons. Here, the authors show that tRNA expression is cyclic and that codon usage, therefore, can give rise to cell-cycle regulation of proteins.