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American Academy of Sleep Medicine, Journal of Clinical Sleep Medicine, 03(04), p. 248-254, 2008

DOI: 10.5664/jcsm.27188

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Increased Heart Rate Variability but Normal Resting Metabolic Rate in Hypocretin/Orexin-Deficient Human Narcolepsy

Journal article published in 2008 by Rolf Fronczek, J. Gert van Dijk, Sebastiaan Overeem ORCID, Robert Reijntjes ORCID, Gert Jan Lammers, Lammers Gj, J. Gert van Dijk, van Dijk Jg, J. G. M. Dijk, Hanno Pijl
This paper is available in a repository.
This paper is available in a repository.

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Abstract

STUDY OBJECTIVES: We investigated autonomic balance and resting metabolic rate to explore their possible involvement in obesity in hypocretin/orexin-deficient narcoleptic subjects. METHODS: Resting metabolic rate (using indirect calorimetry) and variability in heart rate and blood pressure were determined in the fasted resting state. Subjects included 15 untreated, hypocretin-deficient male narcoleptics and 15 male controls matched for age and body mass index. RESULTS: Spectral power analysis revealed greater heart rate and blood pressure variability in hypocretin-deficient male narcoleptic patients (heart rate: p = 0.01; systolic blood pressure: p = 0.02; diastolic: p