Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

Veerapen, Natacha; Brigl, Manfred; Garg, Salil; Cerundolo, Vincenzo; Cox, Liam R.; Brenner, Michael B.; Besra, Gurdyal S.

Links

ORCID
ORCID
Crossref | PDF
[www.ncbi.nlm.nih.gov] | PDF
[www.researchgate.net] | PDF
[www.ncbi.nlm.nih.gov] | PDF
[www.ncbi.nlm.nih.gov] | PDF

Tools

Export citation

Search in Google Scholar

Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

Journal article published in 2009 by Natacha Veerapen

, Manfred Brigl, Salil Garg, Vincenzo Cerundolo, Liam R. Cox, Michael B. Brenner, Gurdyal S. Besra

This paper is available in a repository.

Full text: Download

Preprint: policy unknown

Upload

Postprint: policy unknown

Upload

Published version: policy unknown

Upload

Abstract

We herein report a faster and less cumbersome synthesis of the biologically attractive, alpha-galactosyl ceramide (alpha-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal(alpha1-->2)GalCer, which has been shown to require uptake and processing to the biologically active alpha-GalCer derivative.