We present here the complete genome sequence of Corynebacterium pseudotuberculosis strain 12C, isolated from a sheep abscess in the Brazil. The sequencing was performed with the Ion Torrent Personal Genome Machine (PGM) system, a fragment library, and a coverage of ~48-fold. The genome presented is a circular chromosome with 2,337,451 bp in length, 2,119 coding sequences, 12 rRNAs, 49 tRNAs, and a G+C content of 52.83%. FOOTNOTES Address correspondence to Vasco Azevedo, vasco{at}icb.ufmg.br. Citation Sousa TJ, Mariano D, Parise D, Parise M, Viana MVC, Guimarães LC, Benevides LJ, Rocha F, Bagano P, Ramos R, Silva A, Figueiredo H, Almeida S, Azevedo V. 2015. Complete genome sequence of Corynebacterium pseudotuberculosis strain 12C. Genome Announc 3(4):e00759-15. doi:10.1128/genomeA.00759-15. Received 8 June 2015. Accepted 12 June 2015. Published 16 July 2015. Copyright © 2015 Sousa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.