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Oxford University Press, Nucleic Acids Research, 1(26), p. 320-322, 1998

DOI: 10.1093/nar/26.1.320

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Pfam: Multiple Sequence Alignments and HMM-Profiles of Protein Domains

Journal article published in 1970 by Sean R. Eddy, Ewan Birney ORCID, Alex Bateman, Erik L. L. Sonnhammer, Richard Durbin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Pfam contains multiple alignments and hidden Markov model based profiles (HMM-profiles) of complete protein domains. The definition of domain boundaries, family members and alignment is done semi-automatically based on expert knowledge, sequence similarity, other protein family databases and the ability of HMM-profiles to correctly identify and align the members. Release 2.0 of Pfam contains 527 manually verified families which are available for browsing and on-line searching via the World Wide Web in the UK at http://www.sanger.ac.uk/Pfam/ and in the US at http://genome.wustl. edu/Pfam/ Pfam 2.0 matches one or more domains in 50% of Swissprot-34 sequences, and 25% of a large sample of predicted proteins from the Caenorhabditis elegans genome.