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MDPI, Marine Drugs, 7(11), p. 2655-2666, 2013

DOI: 10.3390/md11072655

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Antioxidant and Anti-Inflammatory Activities of Barettin

Journal article published in 2013 by Karianne F. Lind, Espen Hansen, Bjarne Østerud, Karl-Erik Eilertsen, Annette Bayer ORCID, Magnus Engqvist, Kinga Leszczak, Trond Ø. Jørgensen, Trond O. Jørgensen, Jeanette H. Andersen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis.