Published in
Nature Research, Nature Genetics, 8(41), p. 876-878, 2009
DOI: 10.1038/ng.417
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- [www.ncbi.nlm.nih.gov] | PDF
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- [europepmc.org] | PDF
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A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
,
Hilma Holm,
Solveig Gretarsdottir,
Gudmar Thorleifsson,
G. Bragi Walters,
G. Bragi Walters,
Gudmundur Thorgeirsson,
Jeffrey Gulcher,
Ellisiv B. Mathiesen,
Inger Njølstad,
Audhild Nyrnes,
Tom Wilsgaard,
Erin M. Hald,
Kristian Hveem,
Camilla Stoltenberg
and other authors.
Full text: Download
Abstract
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.