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BMJ Publishing Group, Annals of the Rheumatic Diseases, 11(66), p. 1411-1418

DOI: 10.1136/ard.2006.067793

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Cellular targets of interleukin‐18 in rheumatoid arthritis

Journal article published in 2007 by Sheng‐Ming-M. Dai, Zheng‐Zheng-Z. Shan, Huji Xu ORCID, Kusuki Nishioka
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Recent data are presented which indicate a critical role for interleukin (IL)‐18 in rheumatoid arthritis (RA). The T cells and macrophages invading the synovium or in the synovial fluid are the chief cellular targets of IL‐18 in RA. Neutrophils, dendritic cells and endothelial cells may also be cellular mediators of IL‐18. The direct effect of IL‐18 on fibroblast‐like synoviocytes or chondrocytes may not be essential or important. In RA, IL‐18, which is mainly produced by macrophages, activates T cells and macrophages to produce proinflammatory cytokines, chemokines, adhesion molecules and RANKL which, in turn, perpetuate chronic inflammation and induce bone and cartilage destruction.