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Elsevier, Fitoterapia, 4(82), p. 528-533

DOI: 10.1016/j.fitote.2010.12.003

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Phytoconstituents from Vitex agnus-castus fruits

Journal article published in 2010 by Shao-Nong Chen, J. Brent Friesen, Donna Webster, Dejan Nikolic, Richard B. van Breemen, Z. Jim Wang, Harry H. S. Fong, Norman R. Farnsworth, Guido F. Pauli ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic method (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.