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Elsevier, HPB, 4(13), p. 240-245, 2011

DOI: 10.1111/j.1477-2574.2010.00277.x

Surgery, Gastroenterology and Oncology, 6(23), p. 373, 2018

DOI: 10.21614/sgo-23-6-373

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Prognostic significance of lymph node ratio after resection of peri-hilar cholangiocarcinoma

Journal article published in 2011 by Alfredo Guglielmi, Andrea Ruzzenente, Andrea Ruzzenete, Tommaso Campagnaro, Silvia Pachera, Alessandro Valdegamberi, Simone Conci ORCID, Marco Sandri, Fabio Bagante, Calogero Iacono
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This paper is available in a repository.

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Abstract

Lymph node (LN) metastases are a major negative prognostic factor for peri-hilar cholangiocarcinoma (PCC). Prognostic significance of the extent of LN dissection, number of metastatic LN and the lymph node ratio (LNR) are still under debate.The aims of the present study were to evaluate the prognostic value of the LN status, the total number of LNs evaluated and LNR in PCC.Between 1990 and 2008, 62 patients with PCC submitted to surgical resection with curative intent were retrospectively evaluated. Number and status of harvested LN were recorded.In 53 patients (85.4\%) regional lymphadenectomy was performed. Median number of LNs examined was 7 (range 1-25). Median survival was 41.9 months in patients with N0 compared with 22.7 months in 21 patients (39.6\%) with N+ (P= 0.03). Median survival was 3, 18.5 and 29 months for patients with 0, 1-3 and >3 LN retrieved, respectively (P