Published in
Wiley, Angewandte Chemie International Edition, 12(50), p. 2795-2798, 2011
Wiley, Angewandte Chemie, 12(123), p. 2847-2850, 2011
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Tandem Acyl Carrier Proteins in the Curacin Biosynthetic Pathway Promote Consecutive Multienzyme Reactions with a Synergistic Effect**
Journal article published in 2011 by
Liangcai Gu,
Eli B. Eisman,
Somnath Dutta,
Titus M. Franzmann 
,
Stefan Walter,
William H. Gerwick,
Georgios Skiniotis,
David H. Sherman
,
Stefan Walter,
William H. Gerwick,
Georgios Skiniotis,
David H. Sherman
This paper is made freely available by the publisher.
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Abstract
Synergistic gathering: Biochemical studies reveal a highly efficient strategy in biosynthesis to promote consecutive multienzyme reactions. In the curacin A pathway, catalytic efficiency of a multi-step modification process and one-step translocation is significantly enhanced by tandem organization and dimerization of the ACP3 tridomain with an unexpected synergistic effect (see scheme).