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Japan Academy, Proceedings of the Japan Academy, Series B Physical and Biological Sciences, 6(86), p. 563-577, 2010

DOI: 10.2183/pjab.86.563

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Pancreatic .BETA.-cell signaling: toward better understanding of diabetes and its treatment

Journal article published in 2010 by Susumu Seino, Tadao Shibasaki, Kohtaro Minami ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Pancreatic beta-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the beta-cells and/or a decrease in the beta-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and beta-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies.