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Public Library of Science, PLoS ONE, 5(4), p. e5489, 2009

DOI: 10.1371/journal.pone.0005489

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Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α

Journal article published in 2009 by Lie Li, Claudia E. Oropeza, Bruno Sainz, Susan L. Uprichard, Frank J. Gonzalez, Alan McLachlan ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4alpha links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability.