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Oxford University Press, Clinical and Experimental Immunology, 1(156), p. 61-68, 2009

DOI: 10.1111/j.1365-2249.2008.03867.x

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Constitutive expression of Bcl-2 in the haematopoietic compartment alters the metabolism of iron and increases resistance to mycobacterial infection

Journal article published in 2009 by M. Flórido, M. Borges ORCID, P. Rodrigues, S. Vale-Costa ORCID, M. Salomé Gomes, M. Salomé Gomes, R. Appelberg
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Summary Mice expressing a vav-bcl-2 transgene were tested for their resistance to an experimental infection with Mycobacterium avium. When compared with control littermates, transgenic mice exhibited an increase in the resistance to infection which was independent of B or T lymphocytes and did not require the production of gamma interferon. Macrophages from both control and transgenic mice showed equal permissiveness to M. avium growth in vitro. Finally, transgenic mice expressed diminished circulating iron levels which correlated with the increased resistance to infection.