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Public Library of Science, PLoS ONE, 11(5), p. e15492, 2010

DOI: 10.1371/journal.pone.0015492

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S-Adenosyl-Methionine and Betaine Improve Early Virological Response in Chronic Hepatitis C Patients with Previous Nonresponse

Journal article published in 2010 by Magdalena Filipowicz, Christine Bernsmeier ORCID, Luigi Terracciano, Francois H. T. Duong, Markus H. Heim ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Treatment of chronic hepatitis C (CHC) with pegylated interferon (pegIFN ) and ribavirin results in a sustained response in approximately half of patients. Viral interference with IFN signal transduction through the Jak-STAT pathway might be an important factor underlying treatment failure. S-adenosyl-L-methionine (SAMe) and betaine potentiate IFN signaling in cultured cells that express hepatitis C virus (HCV) proteins, and enhance the inhibitory effect of IFN on HCV replicons. We have performed a clinical study with the aim to evaluate efficacy and safety of the addition of SAMe and betaine to treatment of CHC with pegIFN /ribavirin.