Drastic improvements in styrene yield and selectivity were achieved in the oxidative dehydrogenation of ethylbenzene by staged feeding of O-2. Six isothermal packed bed reactors were used in series with intermediate feeding of O-2, while all EB was fed to the first reactor, diluted with helium or CO2 (1:5 molar ratio), resulting in total O-2:EB molar feed ratios of 0.2-0.6. The two catalyst samples, gamma-Al2O3 and 5P/SiO2, that were applied both benefitted from this operation mode. The ethylbenzene conversion per stage and the selectivity to styrene were significantly improved. The production of COx was effectively reduced, while the selectivity to other side products remained unchanged. Compared with co-feeding at a total O-2:EB molar feed ratio of 0.6, by staged feeding the EB conversion (+15% points for both catalysts), ST selectivity (+4% points for both samples) and O-2 (ST) selectivity (+9% points for gamma-Al2O3 and +17% points for 5P/SiO2) all improved. The ethylbenzene conversion over 5P/SiO2 can be increased from 18% to 70% by increasing the number of reactors from I to 6 with each reactor a total amount of 02 of 0.1 without the loss of ST selectivity (93%). For 5P/SiO2 a higher temperature (500 degrees C vs. 450 e C for Al2O3) is required. Essentially more catalyst (5P/SiO2) was required to achieve full O-2 conversion in each reactor. Staged feeding of O-2 does not eliminate the existing issues of the catalyst stability both in time-on stream and as a function of the number of catalyst regenerations (5P/SiO2), or the relatively moderate performance (relatively low styrene selectivity for gamma-Al2O3).