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BMJ Publishing Group, Annals of the Rheumatic Diseases, 12(71), p. 1973-1979, 2012

DOI: 10.1136/annrheumdis-2011-201009

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Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome

Journal article published in 2012 by Julia L. Newton, James Frith, Danielle Powell, Kate Hackett, Katharine Wilton, Simon Bowman, Elizabeth Price, Colin Pease, Jacqueline Andrews, Paul Emery, John Hunter, Monica Gupta, Saravanan Vadivelu, Ian Giles, David Isenberg and other authors.
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This paper is available in a repository.

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Abstract

Objectives: To determine the prevalence of autonomic dysfunction (dysautonomia) among patients with primary Sjögren's syndrome (PSS) and the relationships between dysautonomia and other clinical features of PSS. Methods: Multicentre, prospective, cross-sectional study of a UK cohort of 317 patients with clinically well-characterised PSS. Symptoms of autonomic dysfunction were assessed using a validated instrument, the Composite Autonomic Symptom Scale (COMPASS). The data were compared with an age- and sex-matched cohort of 317 community controls. The relationships between symptoms of dysautonomia and various clinical features of PSS were analysed using regression analysis. Results: COMPASS scores were significantly higher in patients with PSS than in age- and sex-matched community controls (median (IQR) 35.5 (20.9-46.0) vs. 14.8 (4.4-30.2), p32.5, a cut-off value indicative of autonomic dysfunction. Furthermore, the COMPASS total score correlated independently with EULAR Sjögren's Syndrome Patient Reported Index (a composite measure of the overall burden of symptoms experienced by patients with PSS) (β=0.38, p