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Cell Press, Cancer Cell, 2(28), p. 270, 2015

DOI: 10.1016/j.ccell.2015.07.009

Cell Press, Cancer Cell, 6(27), p. 780-796, 2015

DOI: 10.1016/j.ccell.2015.04.017

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A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

Journal article published in 2015 by Deepitha Selvaraj, Christoph W. Michalski, Martina Kurejova, Sebastian Stösser, Kshitij Srivastava, Matthias Schweizerhof, Johannes Waltenberger, Paul Heppenstall, Masabumi Shibuya, Rohini Kuner, Vijayan Gangadharan ORCID, Napoleone Ferrara, Hellmut G. Augustin
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life. Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain. Tumor-derived VEGF-A, PLGF-2, and VEGF-B augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models. Sensory-neuron-specific genetic deletion/silencing or local or systemic blockade of VEGFR1 prevented tumor-induced nerve remodeling and attenuated cancer pain in diverse mouse models in vivo. These findings identify a therapeutic potential for VEGFR1-modifying drugs in cancer pain and suggest a palliative effect for VEGF/VEGFR1-targeting anti-angiogenic tumor therapies.