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American Society for Microbiology, Journal of Virology, 16(88), p. 9472-9475, 2014

DOI: 10.1128/jvi.01464-14

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Epithelial Immunization Induces Polyfunctional CD8+ T Cells and Optimal Mousepox Protection

Journal article published in 2014 by Adam R. Hersperger, Nicholas A. Siciliano, Brian C. DeHaven, Adam E. Snook ORCID, Laurence C. Eisenlohr
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8 + T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents.