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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(58), p. 4941-4943, 2014

DOI: 10.1128/aac.03252-14

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Posaconazole Concentrations in Human Tissues after Allogeneic Stem Cell Transplantation

Journal article published in 2014 by Ola Blennow, Erik Eliasson, Tommy Pettersson, Anton Pohanka, Attila Szakos, Ibrahim El-Serafi, Moustapha Hassan, Olle Ringdén, Jonas Mattsson ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain. Copyright © 2014, American Society for Microbiology. All Rights Reserved.