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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(58), p. 4957-4960, 2014

DOI: 10.1128/aac.02350-14

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Multidisciplinary Analysis of a Nontoxigenic Clostridium difficile Strain with Stable Resistance to Metronidazole

Journal article published in 2014 by Ines Moura, Marc Monot, Chiara Tani, Patrizia Spigaglia, Fabrizio Barbanti, Nathalie Norais, Bruno Dupuy, Emilio Bouza ORCID, Paola Mastrantonio
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Stable resistance to metronidazole in a nontoxigenic Clostridium difficile strain was investigated at both the genomic and proteomic levels. Alterations in the metabolic pathway involving the pyruvate-ferredoxin oxidoreductase were found, suggesting that reduction of metronidazole, required for its activity, may be less efficient in this strain. Proteomic studies also showed a cellular response to oxidative stress.