Published in
Public Library of Science, PLoS ONE, 8(10), p. e0135428, 2015
DOI: 10.1371/journal.pone.0135428
Links
- ORCID
- ORCID
- Public Library of Science
- [www.ncbi.nlm.nih.gov] | PDF
- [hdl.handle.net] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [spiral.imperial.ac.uk] | PDF
Tools
Regional Distribution and Evolution of Gray Matter Damage in Different Populations of Multiple Sclerosis Patients
,
Roberta Magliozzi,
Marco Castellaro ,
Aldo Morra,
Antonio Scalfari,
Gabriele Farina,
Chiara Romualdi,
Alberto Gajofatto,
Marco Pitteri,
Maria Donata Benedetti,
Salvatore Monaco
Full text: Download
Abstract
BACKGROUND: Both gray-matter (GM) atrophy and lesions occur from the earliest stages of Multiple Sclerosis (MS) and are one of the major determinants of long-term clinical outcomes. Nevertheless, the relationship between focal and diffuse GM damage has not been clarified yet. Here we investigate the regional distribution and temporal evolution of cortical thinning and how it is influenced by the local appearance of new GM lesions at different stages of the disease in different populations of MS patients. METHODS: We studied twenty MS patients with clinically isolated syndrome (CIS), 27 with early relapsing-remitting MS (RRMS, disease duration