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American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 8(184), p. 928-938, 2011

DOI: 10.1164/rccm.201102-0271oc

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Enhancing Nrf2 Pathway by Disruption of Keap1 in Myeloid Leukocytes Protects against Sepsis

Journal article published in 2011 by Xiaoni Kong, Rajesh Thimmulappa, Florin Craciun, Christopher Harvey, Anju Singh, Ponvijay Kombairaju, Sekhar P. Reddy, Daniel Remick ORCID, Shyam Biswal
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Rationale: Sepsis syndrome is characterized by inappropriate amplified systemic inflammatory response and bacteremia that promote multiorgan failure and mortality. Nuclear factor–erythroid 2 p45-related factor 2 (Nrf2) regulates a pleiotropic cytoprotective defense program including antioxidants and protects against several inflammatory disorders by inhibiting oxidative tissue injuries. However, the role of enhanced Nrf2 activity in modulating innate immune responses to microbial infection and pathogenesis of sepsis is unclear.