Near infrared (NIR) instruments in combination with multivariate data calibration models are useful tools in process monitoring. However, the need for expert assistance with calibration and maintenance of the models is a bottleneck limiting their more widespread use. In the previous article [ NIR news26(8), 13–16 (2015)], the MATLAB graphical application called Fulgur was introduced. Fulgur was developed as part of the BIOPRO “Hands Free” project with the goal of developing automated methods for handling data sets and calibrations of partial least squares models for NIR instruments. In this article, the Model-View-Controller programming design principles needed for developing the application are described in more depth as an introduction for potential developers who may want to use and expand the Fulgur framework. The programing design principles may also be of interest to chemometricians who want to program and develop their own GUI applications in MATLAB. The source code for the application together with more in-depth user and developer guides and tutorials for programming plugins is available for download from models.life.ku.dk.