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Nature Research, Nature Neuroscience, 6(16), p. 665-667, 2013

DOI: 10.1038/nn.3397

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Convergent cortical innervation of striatal projection neurons

Journal article published in 2013 by Geraldine J. Kress ORCID, Naoki Yamawaki, David L. Wokosin, Ian R. Wickersham, Gordon M. G. Shepherd, D. James Surmeier, D. James Surmeier
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons responded to both intratelencephalic and pyramidal tract activation, arguing that these cortical networks innervate both striatal projection neurons.