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Society of Photo-optical Instrumentation Engineers, Journal of Biomedical Optics, 04(15), p. 1, 2010

DOI: 10.1117/1.3469829

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Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes

Journal article published in 2010 by Chulhong Kim, Todd N. Erpelding, Konstantin I. Maslov, Ladislav Jankovic, Walter J. Akers ORCID, Liang Song, Samuel Achilefu, Julie A. Margenthaler, Michael D. Pashley, Lihong V. Wang
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles for pulsed laser light delivery enables photoacoustic image-guided insertion of a needle into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong photoacoustic contrast of the needle is achieved. After subcutaneous injection of the dye in the left forepaw, sentinel lymph nodes are easily detected, in vivo and in real time, beneath 2-cm-thick chicken breast overlaying the axillary region. ICG uptake in axillary lymph nodes is confirmed with fluorescence imaging both in vivo and ex vivo. These results demonstrate the clinical potential of this handheld photoacoustic system for facile identification and needle biopsy of sentinel lymph nodes for cancer staging and metastasis detection in humans.