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BioMed Central, BMC Developmental Biology, 1(9), 2009

DOI: 10.1186/1471-213x-9-58

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The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line

Journal article published in 2009 by Anna Pistocchi, Carmen Gloria Feijóo, Pablo Cabrera, Eduardo J. Villablanca ORCID, Miguel L. Allende, Franco Cotelli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background The lateral line system in zebrafish is composed of a series of organs called neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells, surrounded by accessory cells. Results In this report we describe zebrafish prox1 mRNA expression in the migrating primordium and in the neuromasts of the posterior lateral line. Furthermore, using an antibody against Prox1 we characterize expression of the protein in different cell types within neuromasts, and we show distribution among the supporting cells and hair cells. Conclusion Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.