Published in
American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 7(177), p. 730-742, 2008
DOI: 10.1164/rccm.200708-1233oc
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- [www.ncbi.nlm.nih.gov] | PDF
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Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice
Journal article published in 2008 by
Marcus A. Mall,
Jack R. Harkema,
Joanna B. Trojanek 
,
Diana Treis,
Alessandra Livraghi,
Susanne Schubert,
Zhe Zhou,
Silvia M. Kreda,
Stephen L. Tilley,
Elizabeth J. Hudson,
Wanda K. O'Neal,
Richard C. Boucher
,
Diana Treis,
Alessandra Livraghi,
Susanne Schubert,
Zhe Zhou,
Silvia M. Kreda,
Stephen L. Tilley,
Elizabeth J. Hudson,
Wanda K. O'Neal,
Richard C. Boucher
This paper is available in a repository.
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Abstract
Rationale: Chronic obstructive pulmonary disease is a leading cause of death worldwide, but its pathogenesis is not well understood. Previous studies have shown that airway surface dehydration in β-epithelial Na+ channel (βENaC)–overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors.