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American Chemical Society, Organic Letters, 13(9), p. 2517-2520, 2007

DOI: 10.1021/ol0707665

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Efficient Synthesis of 5-Amido-3-hydroxy-4-pyrones as Inhibitors of Matrix Metalloproteinases

Journal article published in 2007 by Yi-Long Yan, Seth M. Cohen ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

3-Hydroxy-4-pyrones are a class of important metal chelators with versatile medicinal applications. An efficient pathway for the preparation of new 5-amido-3-hydroxy-4-pyrone derivatives has been developed. The synthesized 5-amido-3-hydroxy-4-pyrones have been evaluated as inhibitors of matrix metalloproteinases.