Published in
Oxford University Press, The American Journal of Clinical Nutrition, 3(101), p. 646-658, 2015
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High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.
Journal article published in 2015 by
Ke E. Christensen,
Lg G. Mikael,
Ky-Y. Leung,
Nancy Lévesque,
Liyuan Deng,
Qing Wu,
Ov V. Malysheva,
Ana Best,
Marie A. Caudill,
Nicholas De Greene,
Nd D. Greene 
,
Rima Rozen
,
Rima Rozen
This paper is available in a repository.
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Abstract
Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions.