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Mary Ann Liebert, Antioxidants and Redox Signaling, 8(17), p. 1053-1065, 2012

DOI: 10.1089/ars.2012.4518

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Concomitant Activation of miR-107/PDCD10 and Hypoxamir-210/Casp8ap2 and Their Role in Cytoprotection During Ischemic Preconditioning of Stem Cells

Journal article published in 2012 by Ha Won Kim ORCID, Faryal Mallick, Shazia Durrani, Muhammad Ashraf, Shujia Jiang, Khawaja Husnain Haider
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Aims: To establish a functional link between microRNA-107 (miR-107) and stem cell survival during ischemic preconditioning (IPC) of stem cells with multiple cycles of brief anoxia/re-oxygenation (10 or 30 min, one to three cycles) and show that the cytoprotective effects were independent of hypoxamir-210. Results: We demonstrated the induction of miR-107 in response to the IPC-induced activation of Akt/hypoxia inducible factor-1α (HIF-1α) in preconditioned mesenchymal stem cells (PCMSC), which showed improved survival during subsequent exposure to 6 h of lethal anoxia (p