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Sociedade Brasileira de Química, SBQ, Journal of the Brazilian Chemical Society, 2(24), p. 179-183, 2013

DOI: 10.1590/s0103-50532013000200002

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Synthesis of novel isatin-type 5'-(4-Alkyl/Aryl-1H-1,2,3-triazoles) via 1,3-dipolar cycloaddition reactions

Journal article published in 2013 by Silva,Bianca N. M., Silva,Bárbara, Bianca N. M. Silva, Bárbara V. Silva, Silva,Fernando C., Daniel T. G. Gonzaga, Fernando C. Silva ORCID, Vitor F. Ferreira ORCID, Gonzaga,Daniel T. G., Angelo C. Pinto, Ferreira,Vitor F., Pinto,Angelo C.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Isatin and 1H-1,2,3-triazoles are two classes of compounds with great prominence in organic synthesis and medicinal chemistry as they are heterocycle nuclei with a high reactivity allowing to obtain several compounds with important biological properties. Herein, the synthesis of novel 5'-(4-alquil/aril-1H-1,2,3-triazole)-isatin via reaction of 1,3-dipolar cycloaddition catalyzed by acetic acid is reported.