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Public Library of Science, PLoS ONE, 6(4), p. e5894, 2009

DOI: 10.1371/journal.pone.0005894

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Erythropoietin Over-Expression Protects against Diet-Induced Obesity in Mice through Increased Fat Oxidation in Muscles

Journal article published in 2009 by Pernille Hojman, Camilla Brolin, Hanne Gissel, Claus Brandt, Bo Zerahn, Bente Klarlund Pedersen, Julie Gehl ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Erythropoietin can be over-expressed in skeletal muscles by gene electrotransfer, resulting in 100-fold increase in serum EPO and significant increases in haemoglobin levels. Earlier studies have suggested that EPO improves several metabolic parameters when administered to chronically ill kidney patients. Thus we applied the EPO over-expression model to investigate the metabolic effect of EPO in vivo.