Published in
Public Library of Science, PLoS ONE, 2(7), p. e32306, 2012
DOI: 10.1371/journal.pone.0032306
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- Public Library of Science
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- [www.ncbi.nlm.nih.gov] | PDF
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- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Combined Chromatin and Expression Analysis Reveals Specific Regulatory Mechanisms within Cytokine Genes in the Macrophage Early Immune Response
Journal article published in 2012 by
Maria Jesus Iglesias 
,
Sarah-Jayne Reilly,
Olof Emanuelsson,
Bengt Sennblad,
Mohammad Pirmoradian Najafabadi,
Mohammad Pirmoradian Najafabadi,
Lasse Folkersen,
Anders Mälarstig,
Jens Lagergren,
Per Eriksson,
Anders Hamsten,
Jacob Odeberg
,
Sarah-Jayne Reilly,
Olof Emanuelsson,
Bengt Sennblad,
Mohammad Pirmoradian Najafabadi,
Mohammad Pirmoradian Najafabadi,
Lasse Folkersen,
Anders Mälarstig,
Jens Lagergren,
Per Eriksson,
Anders Hamsten,
Jacob Odeberg
This paper is made freely available by the publisher.
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Abstract
Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS).