Dissemin is shutting down on January 1st, 2025

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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(55), p. 1290-1292, 2011

DOI: 10.1128/aac.01282-10

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In VitroActivity andIn VivoEfficacy of Anidulafungin in Murine Infections byAspergillus flavus

Journal article published in 2010 by Enrique Calvo, F. Javier Pastor, Emilio Mayayo, Valentina Salas, Josep Guarro ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Anidulafungin (AFG) showed high activity against 27 strains of Aspergillus flavus by use of broth microdilution and disk diffusion methods. This drug was effective in vivo in a murine model of disseminated infection with five isolates tested. AFG was able to prolong survival and reduce tissue burden of infected mice but not able to reduce galactomannan serum concentrations. The AFG serum levels were above the corresponding minimum effective concentrations (MEC) for all of the strains tested.