Published in

BioMed Central, Genome Biology, 4(9), p. R66

DOI: 10.1186/gb-2008-9-4-r66

Links

Tools

Export citation

Search in Google Scholar

ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?

Journal article published in 2008 by Peter Van Loo, Stein Aerts, Bernard Thienpont ORCID, Bart De Moor, Yves Moreau, Peter Marynen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Abstract We present ModuleMiner, a novel algorithm for computationally detecting cis -regulatory modules (CRMs) in a set of co-expressed genes. ModuleMiner outperforms other methods for CRM detection on benchmark data, and successfully detects CRMs in tissue-specific microarray clusters and in embryonic development gene sets. Interestingly, CRM predictions for differentiated tissues exhibit strong enrichment close to the transcription start site, whereas CRM predictions for embryonic development gene sets are depleted in this region.