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Public Library of Science, PLoS ONE, 7(10), p. e0134325, 2015

DOI: 10.1371/journal.pone.0134325

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The Ultrastructural Localization of Type II, IV, and VI Collagens at the Vitreoretinal Interface

Journal article published in 2015 by Roel Kuijer ORCID, Shao Chong Bu, Roelofje J. van der Worp, Xiao Rong Li, Johanna M. M. Hooymans, Leonoor I. Los
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The vitreoretinal interface is the border of the cortical vitreous and the inner surface of the retina. The adhesion of the cortical vitreous to the ILM, namely vitreoretinal adhesion, involves a series of complex molecular adhesion mechanisms and has been considered as an important pathogenic factor in many vitreoretinal diseases. The presence of type VI collagen at the vitreoretinal interface and its possible interaction with collagens and glycoproteins indicates that type VI collagen may contribute to the vitreoretinal adhesion.