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BMJ Publishing Group, Journal of Medical Genetics, 10(44), p. 670-672, 2007

DOI: 10.1136/jmg.2007.050971

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The IRF5 polymorphism in type 1 diabetes

Journal article published in 2007 by Hui‐Qi-Q. Qu ORCID, Luc Marchand, Rosemary Grabs, Constantin Polychronakos
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increased IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 nuclear family trios type 1 diabetes (T1D) using the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D.